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In cultures of the SEV group, 8,565 DEG (4,464 upregulated, 4,101 downregulated) were found in contrast 2 and 8,894 DEG (4,520 upregulated and 4,374 downregulated) in contrast 4

The real mechanism (lowering the stress hormone cortisol that impairs the prefrontal cortex and hippocampus, plus a GABA-mimetic and mild acetylcholinesterase action)

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It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling

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