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Furthermore, clinical findings from a study involving 81 NSCLC patients treated solely with ICIs showed that those with MET amplification exhibited ICI resistance and had suboptimal PFS [123]

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A recent study on colorectal cancer demonstrated the role of BMP2 in reducing growth, enhancing apoptosis, and decreasing the development of tumors in vivo (Vishnubalaji et al., 2016), supporting that the decreased expression of BMP2 also leads to the progression of prostate cancer ( EGCG was also identified to differentially inhibit TNF- and LPS-mediated activation of NF-B (Zhang et al., 2010a), the key factor of NF-B pathway