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Description
In bipolar disorder, omega-3 had weak support for bipolar depression (+), while NAC was not currently recommended (+/-)

The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP)

The appeal of these agents stems from their capacity to modulate key pathophysiological contributors in atherosclerosis and heart failure, including oxidative stress, chronic vascular inflammation, endothelial dysfunction, dyslipidemia, and mitochondrial energy deficits (Virani et al., 2021)
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Slightly nauseous, first week no significant weight loss, but 2nd & 3rd wk 3 lbs each

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