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Ferreira-Cravo M, Moreira DC & Hermes-Lima M (2023) Glutathione depletion disrupts redox homeostasis in an anoxia-tolerant invertebrate

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In doxorubicin (DOX)-induced cardiomyopathy models, SIRT1 downregulation exacerbates ferroptosis in cardiomyocytes, while its activation reduces oxidative stress and inhibits ferroptosis by increasing the expression of antioxidant enzymes such as GPX4

FOXO4-DRI: FOXO4-D-Retro-Inverso