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Patients with relative contraindications such as hypertension and severe arrhythmia need to undergo medical assessment before engaging in exercise
[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Root-Bernstein R., Turke M., Subhramanyam U.K.T., Churchill B., Labahn J
Bioinformatics 27 , 17391740 (2011)
This amplification of pain signaling within the CNS involves an increased responsiveness of sensory neurons in the spinal cord and higher brain centers to sensory inputs (Woolf, 1983

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