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Here, we report that ALC reduced SREBP2 and HMGCR expression in mouse livers and human hepatoma cells and increased the expression of cholesterol metabolism-related genes, such as Ldlr , in the livers of ALC-fed mice

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moreover, combined ELAVL1 knockdown and telaglenastat treatment uniformly intensified the effects of telaglenastat depletion of the measured metabolites

(2020) 15:e0239506

The reaction is catalyzed by the carnitine acetyltransferase (CrAT, EC:2.3.1.7), which is present in many cell compartments, including the cytosol, the matrix or mitochondria and peroxisomes, as well as the endoplasmic reticulum and nucleus [5, 83, 106]