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As expected, in SCD erythroblasts, DMF treatment induces a strong association of H3K4Me3 and H3K9Ac in the region (Fig

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First, homocysteine is irreversibly converted into cystathionine by the enzyme cystathionine -synthase (CBS), a reaction that strictly requires Vitamin B6 as a cofactor

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Upon release, ADP binds to P2Y1 and P2Y12 receptors, after which P2Y1 activation stimulates phospholipase C, leading to platelet shape changes and the initiation of aggregation [36], [37]