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More importantly, translation-related pathways were also suppressed, including eukaryotic translational elongation, eukaryotic translational initiation, and translation (Fig

Under oxidative stress, DNA methyltransferases DNMT1 and DNMT3B, along with sirtuin SIRT1, relocate to CpG islands (CGIs) and form complexes with PRC2 subunits like EZH2 and EED, leading to localized DNA methylation (172)

The main pathological manifestation of PD is the huge loss of dopaminergic neurons owing to the accumulation of reactive oxygen species (ROS) and the abnormal aggregation of the -synuclein (-syn) protein

As a matter of fact, this protective effect is achieved through the regulation of GSH metabolic pathways, prevention of DNA damage, control of cell proliferation and survival, as well as inhibition of angiogenesis and metastasis [84,85]

However, recent results confirmed that glutamate, acetylcholine, serotonin, and GABA changes may also contribute to the pathology of the diseases

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