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This enhancement is demonstrable through an increase in mitochondrial DNA content, the upregulation of genes integral to mitochondrial biogenesis, and the increased expression of proteins pivotal in oxidative phosphorylation
10.1186/s12944-020-01286-8 71 KomatsuM.KandaT.UraiH.KurokochiA.KitahamaR.ShigakiS.et al (2018)
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By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism
17 , e13762 (2024)
10.3109/s10165-011-0500-1 31
