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Via the activation of TLR4/MAPK signaling in KCs (87), low SAMe levels induce the expression of transforming growth factor- (TGF-) in KCs (89), which in turn leads to the activation of HSCs

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When pentadecapeptide BPC 157 therapy was given in already advanced stage of paracetamol toxicity, such as at 3 hours after initial paracetamol application, only mild liver lesions ( Table 3, Fig