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The exogenous induction of GSH depletion causes mitochondrial-dependent apoptosis in CYP2E1-expressing HepG2 cells (E47 cells) [123]

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(73) demonstrated that CTC clusters exhibit superior survival capacity and proliferative potential compared to single CTCs via integrated breast cancer models combining single CTC/CTC cluster simulations and zebrafish embryo xenografts, with molecular mechanisms linked to cell cycle pathway activation and stemness-associated gene upregulation

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Wolraich et al., 2019)

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doi: 10.1038/s41574-021-00553-7

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