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Proteomic analysis showed that these significantly differentially expressed proteins are involved primarily in metabolic pathways including carbon metabolism, amino acid biosynthesis, pyruvate metabolism, glucagon signaling, pentose phosphate pathway, HIF-1 signaling and glycolysis/gluconeogenesis (Figure 4C)

If MTHFR fails or is unable to perform its functions fully in this step, there will be a problem associated with folates

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10.1186/2050-6511-13-8 BMC Pharmacol