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Zeiser et al., 2013

doi: 10.1159/000105167

Thus, by inhibiting production of DHT and blocking testosterone and DHT from binding to sebocytes, spironolactone has been proven to inhibit sebocyte proliferation in a dose-dependent manner.[47] Prior to starting a female patient on spironolactone for oily skin, several potential side effects need to be addressed

Limit or avoid alcohol intake while using this medicine to minimize interactions and side effects

After the reaction was complete, excessive trimethylamine was removed by distillation under reduced pressure

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