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While short-term, low-dose use may be acceptable for pain management, prolonged NSAID use during the early weeks of fracture healing has been associated with delayed union in some studies

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In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

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Jun 12 2020;255:112768

Experts caution that there are limits to what can be gleaned from these lab experiments and that they cannot be used to definitively say how Omicron may lower vaccine effectiveness in the real world