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doi: 10.1016/S1353-8020(09)70798-9

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It was also verified that one kind of long noncoding RNA, LINC00662, could activate the Wnt/-catenin pathway in an autocrine manner by increasing Wnt3a expression and secretion, and also in a paracrine manner to promote M2 macrophage polarization, leading to HCC tumorigenesis and metastasis in vivo 27 ( Figure 2 )

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Presence of this salt bridge restricts the formation of hydrogen bonds involving residues 23 to 29 between chains (i,i+1) in the DRI fibril, but because of the different staggering not in L-fibrils