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In response to UCB stimulation, IL-1beta, TNF-alpha, NF-B, and MAPK pathways have been shown to serve significant functions in cytotoxicity and cytokine production, which led to UCB-induced neurotoxicity [31]

Kuo HC: Repeated intravesical onabotulinumtoxina injections are effective in treatment of refractory interstitial cystitis/bladder pain syndrome

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251 In a phase II clinical trial (NCT02601950), tazemetostat demonstrated good tolerability and clinical activity, with a low incidence of severe treatment-related adverse events such as anemia and weight loss

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