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However, despite its promising mechanisms, AOD-9604 is not FDA-approved for medical use

B2515) were purchased from Sigma-Aldrich

Peptide-based therapeutics have emerged as promising alternatives, offering high specificity, favorable safety profiles, and unique biological activities compared to traditional treatments

Reducing brain-generated acetaldehyde by silencing catalase or increasing ALDH2 activity in the VTA decreases alcohol-induced-reinforcing effects and reduces voluntary ethanol intake (141)

The mental health relevance is indirect: if DSIP genuinely improves sleep quality, the downstream effects on mood, cognition, and stress resilience could be significant