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For further reading, readers are directed to relevant reviews on related topics [294, 327, 328]

203,204 Our work discovered that the deletion of DDR factor Gadd45a rescued the heterochromatin remodeling via base excision repair-mediated active DNA demethylation in sub-telomeric regions in telomere-deficient cells, which generates an uncondensed chromatin structure to promote DDR signaling

The disease, which was described as Shaking Palsy by its discoverer, James Parkinson in the year 1817 (Goetz, 2011), is caused primarily by death of the dopamine neurons in the Substantia nigra (SN), a region named after the high levels of melanin present in the dopamine neurons in unaffected individuals (Zecca et al., 2003)

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The structural alterations of the products were further verified by FTIR spectra (Supplementary Fig

doi: 10.4081/ijas.2015.3473 117 SkivanMEnglmaierovMTaubnerTSkivanovE