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2 might mediate signaling by affecting protein phosphorylation, depending on the proteins temporal configuration

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& Medina, E

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Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children (Frye et al., 2018)

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Jiang et al., 2015

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Deacetylation is achieved by deacetylases (KDACs), the "erasers", which include Zn 2+ -dependent lysine deacetylases and sirtuins, a group of NAD + -dependent deacetylases (Figure 7)

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On the contrary, healthy tissue displayed higher levels of extracellular oxidative stress, which could be a consequence of better vascularization and therefore oxygen availability in healthy lung tissue: while the reported oxygen concentration for healthy lung tissue is ~5.6%, for lung tumors this value drops to ~2%, and in some extreme cases even to as low as 0.1% 26,27

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