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Description
Troglitazone (Rezulin) [2] [9] and trovafloxacin (Trovan) are two prime examples of idiosyncratic hepatotoxins pulled from market

The antiproliferative effect of the chalcone lonchocarpin, isolated from the plant used in traditional medicine Pongamia pinnata (L.), was studied in ten lung cancer cell lines
Notably, vitamin B1 insufficiency is highly prevalent in diabetic populations (144)

Many neurotransmitters are also involved in this process

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Notably, autophagy dysfunction and metabolic disturbances form a vicious cycle - impaired autophagic flux exacerbates glucose and lipid metabolic imbalances (Kim and Lee, 2014), which may serve as a key driver for the progressive metabolic deterioration in DM (Figure 3)
