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J Biol Regul Homeost Agents 29 , 913923 (2015)

The lack of feedback inhibition during uptake of modified LDL by this unidentified receptor suggested a plausible mechanism for the massive accumulation of cholesterol in macrophages that generates foam cells

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however, the transposon insertion is at the far C terminus, so it is unclear if this is a functional knockout

FPN is the only known transmembrane iron exporter in vertebrates, primarily expressed in duodenal enterocytes, hepatocytes, and macrophages, where it plays a crucial role in maintaining cellular and systemic iron homeostasis (39)

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