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A study showed that Mthfr deficiency in mice exacerbated the PD-like symptoms in Mthfr +/ mice such as motor function impairments, elevated microglial activity in the substantia nigra, and increased oxidative stress in dorsal striatum suggesting that Mthfr deficiency heightens the vulnerability of substantia nigra and dorsal striatum to paraquat-induced damage [171]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Dumont L.J., AuBuchon J.P

This review highlights the key role of CpG islands and their relation to DNA methylation

Group 2: Chemicals that should give negative results in in vitro mammalian cell genotoxicity tests
