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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Okada K, Tanaka H, Temporin K, Okamoto M, Kuroda Y, Moritomo H, Murase T, Yoshikawa H

The initial failure to consider the difficulties associated with cell-free Hb involving both NO complexation and oxidative reactions resulted in very limited use of Hb based blood substitutes until modification can be put in place to minimize these serious side effects

In addition to its antioxidant action, glutathione is also involved in the intracellular neutralization of toxins

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doi: 10.1038/s41591-018-0337-7 38 ZhaoJChenAXGartrellRDSilvermanAMAparicioLChuTet al