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Experiencing memory loss or dementia Issues with concentrating on tasks Persistent lowered mood or depression Mania extreme and uncharacteristically elevated moods Entering non-responsive states, or becoming catatonic Experiencing symptoms associated with schizophrenia Episodes of psychosis, delusions and delirium Other Conditions A variety of other conditions can also cause peripheral neuropathy

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More importantly, the synthesis of SAM, which requires the folate cycle, is crucial in neuropsychiatry for its role as a therapeutic agent in the treatment of depression, and as an antidepressant in Parkinsons disease (, , )

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