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Again this is rare and likely has more to do with preservative and other things in the injection other than cobalmin since our bodies need this molecule to survive
It is worth being clear here: in people with normal B12 levels, injections have not been shown to improve athletic performance or endurance

H., Wang Y

The skin of the injection site should be smooth, and if you are injecting intramuscularly then its important that the muscle is relaxed

May Reduce Depression Risk Studies into depression have suggested that low B12 can be a cause of a depressed mood
