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Wadden, T.A

Abbreviations AICD: Amyloid precursor protein intracellular domain APP: Amyloid precursor protein BDNF: Brain-derived neurotrophic factor CHOP: CCAAT enhancer-binding protein homologous protein C/N: Carbon to nitrogen ERK: Extracellular-signal-regulated kinase IDE: Insulin-degrading enzyme iNOS: Inducible NO synthase IRE1 : Inositol-requiring enzyme 1 JNK: c-Jun N-terminal protein kinase MAPK: Mitogen-activated protein kinase MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPP + : 1-Methyl-4-phenylpyridinium NeuN: Neuronal nuclei NF- B: Nuclear factor kappa light chain enhancer of activated B cells NGF: Nerve growth factor PD: Parkinson's disease proNGF: NGF precursor RNS: Reactive nitrogen species TRAF2: Tumor necrosis factor receptor-associated factor 2 v / v : Volume/volume

B Complex- combination of B vitamins useful for metabolism, sleep, irritability, fatigue, mental health, and more

Recent transcriptomic and panomic studies suggest that Mg may also exert epigenetic control over stress-responsive genes via chromatin remodeling and DNA methylation, owing to its role as a cofactor for enzymes involved in methyl group transfer

For effective results, it is recommended to take the pills with main meals i.e., after breakfast, lunch, and dinner

Wang et al., 2018b