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This process also opens the mitochondrial permeability transition pore (mPTP) and enhances the stimulation of autophagosome formation and mitophagy

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In addition, an increase in acidic vesicular organelles (AVOs) and in LC3 II protein expression produced by NaDOC means that autophagy might be another mechanism triggered by this bile salt associated with the inhibition of the intestinal Ca 2+ absorption[22] (Table 1)

Notably, the expression of HO-1 is regulated by Nrf2, and the nuclear translocation of Nrf2 is inhibited by KEAP1

Funding This work was supported by the National Key R&D Program of China (grant number: 2023YFC3404100, 2023YFC2506400), and National Natural Science Foundation of China (grant number: 82325042, 82203860), and Shanghai Municipal Education Commission Scientific Research Innovation Project (grant number: 2023-05-50), Wu Jieping Medical Foundation Research Project (grant number: 32067502023-18-29)

Meningeal lesions that destroy the arachnoid villi can lead to external hydrocephalus