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The predictors of pemetrexed toxicities were poor Eastern Cooperative Oncology Group performance status (ECOG-PS) and low body mass index (BMI) for febrile neutropenia (FN), concomitant chronic infectious disease, bevacizumab use for neutropenia, poor ECOG-PS for thrombocytopenia, and low serum albumin levels for non-hematologic toxicities

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SSRIs like Prozac increase serotonin levels, which can sometimes affect gut motility, leading to diarrhea

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We also believe that additional specification in terms of type or use on the term padding that is provided as an example in the definition is not necessary to clarify the scope of the benefit and are finalizing the definition as proposed