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Protects Against Environmental Damage: The antioxidant properties of L-Glutathione help to protect the skin against damage from free radicals, which are caused by environmental factors such as pollution and UV radiation

2006;10:R155

NAD+ helps produce NADPH (the energy that keeps Glutathione active), while Glutathione helps reduce oxidative stress, which protects and preserves NAD+

Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H et al

Using them twice daily when your skin only needs them once, or applying a high-concentration serum when a moderate one would suffice, can overwhelm your skin's ability to maintain its moisture barrier

Yes, if taken under medical supervision and proper dosage