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Curr Mol Med 25(4):372387 Kuwar OK, Singh S (2025) Baicalein-mediated regulation of Nrf2/ARE, NFB, and MAPK signaling in Huntingtons disease: a promising strategy against neuroinflammation and neurodegeneration

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[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing