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Experiments were conducted using DIO male C57BL/6J mice (Janvier Labs) kept on a HFHS diet (58 kcal% fat, D12331i, Research Diets) from 8 weeks of age

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Compounds such as NSC232003, 362 UM63, 363 UF146, 364 chicoric acid, 365 have been shown to block the interaction between UHRF1 and 5mC sites, effectively preventing the proliferation of diverse cancer cell lines