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Human data are limited

By weeks 3-4, users following a consistent caloric deficit may notice subtle changes: slightly looser-fitting clothing around the midsection, a minor reduction in waist measurement (0.5-1 cm), and potentially 0.5-1 kg of fat loss on top of what diet alone would produce

Overexpression of NNMT is associated with obesity and type 2 diabetes, as it slows fat cell metabolism

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Suddenly the old lady had pep in her step, Nix reports