5-amino-1mq and cd38 inhibitor combination benefits Comment “curious” for the full newsletter. 👇 There's a new metabolic regulator making waves. In preclinical studies, it: ↑ grip strength ~40%, ↑ muscle size, ↑ endurance, ↓ fat mass It may CD38 as theranostic target in

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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict

Usually, you get injections weekly at first

The peptide does not appear to significantly affect glucose metabolism or insulin sensitivity in the way that full-length growth hormone does - growth hormone causes insulin resistance through various mechanisms, whereas AOD9604 has been reported to be neutral or possibly even beneficial for insulin sensitivity

link Neelakantan H, Vance V, Wetzel MD, et al

Tablets remain stable for 24 months