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many of these transporters are Na + -dependent, and hence, the astrocytic 2-containing Na + K + pump is central for astrocytes homeostatic capacity 20

doi: 10.1016/j.nefro.2015.05.022, PMID: [DOI] [PubMed] [Google Scholar] 126.Rayego-Mateos S, Valdivielso JM

26 , 18151827.e5 (2019)

If ETC function is impaired, the TCA cycle can continue to generate metabolites by reductive mechanisms, including using pyruvate carboxylase to generate oxaloacetate from pyruvate for aspartate production, and glutamine-dependent reductive carboxylation for citrate synthesis (22, 23)

Nutrients (2021) 13(6):2010

Too much glutamate can be toxic to neurons and cause neuronal death
