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We demonstrated that GSH supplementation directly inhibits the production of mature viral particles by interfering with virus envelope glycoproteins

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The authors show that the drastic growth arrest of the sir1 mutant is partially rescued when glutathione deficiency is introduced via the cad2 mutation, which decreases glutathione levels to 30% to 40% of wild-type levels (Cobbett et al., 1998), or pharmacologically through treatment with the GCL inhibitor buthionine sulfoximine

Elevated hippurate, which is a renally cleared nitrogen carrier illustrates an intriguing therapeutic target

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