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Neuroprotective Properties Under Investigation The Zagreb groups 2016 review in Current Neuropharmacology described peripheral BPC-157 administration altering serotonin synthesis rates in specific brain regions, particularly nigrostriatal and other dopaminergic pathways (Tohyama, Sikiric, Diksic, 2004, Life Sciences )

This is achieved by enhancing the activity of endogenous antioxidant enzymes (SOD, CAT, GR, GPx, and GSH) or by inhibiting oxidative stress-induced damage in the reproductive system

However, it's always best to consult with your healthcare provider before starting any new medication or supplement

Nat Rev Endocrinol (2011) 8(3):16071

Drop back to the previous dose and attempt escalation again after an additional 2-4 weeks

Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence