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doi: 10.3390/ijms21041505 59 KayaH.NakajimaR.IwanoM.KanaokaM

This index correlates with patients clinical traits, with higher scores tending to indicate a worse prognosis (111)

Loss of MMR protein expression on IHC guides further testing, including MLH1 promoter methylation testing or direct germline testing, depending on which protein(s) are lost

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Most ipamorelin side effects are tied to normal physiological responses, including: Increased growth hormone pulses IGF-1 signaling changes Temporary fluid and electrolyte shifts Nervous system adaptation during early use In many cases, symptoms improve as the body acclimates or when dosing is adjusted