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A similar relocation was observed when LIPA-mVenus was co-expressed with either SLDP1.3-mCherry or the non-tagged (native) versions of SLDP1.3 or SLDP2.1 (Supplemental Figure 13B)

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Mol Pharmacol(2002) 61: 989-996

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Translational efforts also face substantial pharmacological hurdles, as targeting evolutionarily conserved lipid metabolic enzymes frequently triggers compensatory pathways or unintended metabolic disruptions in nontarget tissues

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