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JAMA 296 , 24412450 (2006)

Providing the closely interrelated increased pressure in the three body cavities interacting with each other rapidly transmitted through the venous system [28,29] (and thereby, venous system as therapy target [20,21,22,23,24,25,26,27]), the occluded superior sagittal sinus in addition to the brain swelling and lesions and increased pressure in the superior sagittal sinus may induce a comparable deadly syndrome

Its overall beneficial effects have led Canada and the US to mandate the fortification of grain-based food products with folic acid since 1998 [35]

& Hoffmann, T