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Ranson H, Collins J, Hemingway J

However, molecular signaling of BSO-induced apoptosis is poorly understood, and, recently, it has been demonstrated that in different leukaemia and lymphoma cells, the death receptor-mediated apoptotic pathway, induced by arsenic trioxide plus BSO, is triggered via JNK activation [58]

However, not only the long periods but also the short periods of CR can be beneficial

Melatonin Melatonin is an antioxidant with neuroprotective properties and has been found to be lowered in patients with Alzheimers disease (Dubey and Singh 2023)

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These symptoms correlated with varying degrees of diffuse and progressive white matter alterations seen on brain MRI in two subjects, and only mild alteration of the upper spinal cord in another