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doi: 10.1021/cr068207j

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These treatment results suggest that the old age increases in Rab7-labeled late endosome and Arl8b-labeled lysosomes are not protective but suffer from insufficient energy to complete the processes of vesicular autophagy via lysosomal degradation
Wei X, Wu Y, Tang H, Wang B, Wang Y, Sun W, Asenso J, Xiao F, Wang C (2021) CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

Haynes, Forest S

However, there is a large variation in how measurements were conducted for plaque size, thereby providing a low evidence base for utilisation clinically
