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P -values are represented as * p 0.05, ** p 0.01, *** p 0.001, **** p 0.0001

Additionally, increased ROS levels contribute to the oxidation of essential biomolecules, including lipids, proteins, and DNA, further exacerbating cellular damage (Juan et al., 2021)

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In addition, specific amino acid deficiency or the immunosuppressive effect of certain amino acid metabolism can damage the function of immune cells, including effector T cells, in the tumor microenvironment

[DOI] [Google Scholar] 872.Ohgami K., Shiratori K., Nitta T., Shinmei Y., Chin S., Yoshida K., Tsukahara H., Ohno S