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Aside from direct effects on principal neurons, a second, hypothesized mechanism for ketamines antidepressant effect is an indirect impact on principal excitatory neurons via inhibition of fast spiking PV-positive interneurons resulting in cortical disinhibition [171,172,173]

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Melansir Medical News Today , glutathione berfungsi mengurangi stres oksidatif atau ketidakseimbangan antara radikal bebas dan antioksidan dalam tubuh yang dapat memicu kerusakan sel-sel tubuh

Lack of rest can increase oxidative stress, draining your glutathione stores faster
