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J Appl Physiol (1985) 105(4):13331341

The most common types of arthritis are osteoarthritis, caused by wear-and-tear of joint cartilage, and rheumatoid arthritis, an autoimmune disease that gradually destroys the cartilage and bone in a joint

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Secondary carnitine depletion due to increased formation and urinary excretion of glutarylcarnitine is suggested to play an important role in the neuropathogenesis of GCDH deficiency, inducing excitotoxic neuronal damage and mitochondrial dysfunction [83]

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doi: 10.1016/j.biopsych.2016.06.017 52 KaufmanMJJanesACHudsonJIBrennanBPKanayamaGKerriganARet al