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This framework covers the majority of research compounds but is a starting point, not a substitute for compound-specific documentation

Additionally, individuals taking medications that may interact with B12, including metformin or proton pump inhibitors, should consult a healthcare provider before starting supplementation

For all RT-qPCR assays, target gene expression levels were normalized by 18S ribosomal RNA (18S ribosomal N1) (NR_145820.1) levels

Sweat production Sweat production is highly variable: low for sedentary people exposed to moderate temperature, it can reach several liters per day during intense physical activity, high ambient temperature, and/or high humidity ( EFSA 2010 )

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Pregnant women maintain the same RNI of 1.5 mcg per day as non-pregnant women