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34,35 Importantly, cynomolgus monkeys exhibit advanced complicated lesions along with vascular calcification, thus providing a basis for translational research, as shown in this study

10.1016/j.neuint.2015.08.014 65

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Differentiation 31, 4249

Significantly, a compound denoted as melatonin-trientine, covalently synthesized with melatonin and the metal ion chelator trientine, demonstrated the capacity to elevate the expression of IDE in a murine AD model, and decreased A deposition and neuronal degeneration in the brains of the APP/Presenilin 1 mice [65]

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