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Its administration can lead to a considerable decline in serum testosterone levels in patients with PCOS [23]

(Bus) Leslie, and Richard Ford

( a ) In silico docking analysis of FAD into HCV NS5B using SwissDock

Graziottin, 2015)

2017 31:1_supplement, 802.5-802.5 [13] Raghubeer S, Matsha TE

Clinical Outcomes of HCV-Related Renal Disease A retrospective cohort study involving more than 470,000 adult veterans showed that persons with chronic HCV infection were more likely to develop end-stage renal disease (4.3 per 1,000 person-years) than HCV-seronegative patients (3.1 per 1,000 person-years).[13] A subsequent cross-sectional study showed that persons with HCV infection had a 40% higher likelihood of developing renal insufficiencydefined as serum creatinine levels greater than or equal to 1.5 mg/dLcompared with seronegative participants.[11] Treatment of HCV in Renal Disease One multicenter observational study of 139 patients with kidney disease from mixed cryoglobulinemia suggested that DAA treatment was associated with reduced mortality and improved kidney survival in that cohort.[56] Successful clearance of HCV with DAA therapy is associated with improved clinical outcomes, including reduced risk of chronic kidney disease and a survival benefit in patients on dialysis.[57,58] The treatment of HCV in persons with renal disease is addressed in detail in this curriculum in the topic review Treatment of HCV in Persons with Renal Impairment