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An increasing body of preclinical and clinical evidence suggests that mitochondrial dysfunction, characterized by bioenergetic failure, heightened oxidative stress, dysregulated calcium handling, and impaired mitophagy, contributes to the etiopathogenesis of both CVDs and cognitive impairment

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Methylenetetrahydrofolate Reductase (MTHFR) genetic variation and major depressive disorder prognosis-a five-year prospective cohort study of primary care attendees

Treatment of primary hepatocytes with the ER stressor tunicamycin (TM) upregulated UPR-responsive mRNAs, and ET cotreatment suppressed this effect (Figure 1A)

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A critical role for CD8 T cells in a nonhuman primate model of tuberculosis