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In vitro , 5-amino-1MQ significantly reduced intracellular MNA, increased intracellular NAD + , and suppressed lipogenesis in adipocytes

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In addition, in research on aging-related muscle atrophy (sarcopenia), it can promote muscle cell proliferation and differentiation, reduce muscle cell apoptosis, and enhance muscle strength and endurance by activating the SIRT1 signaling pathway

[DOI] [PubMed] [Google Scholar] 65.Menon R

Importantly, NNMTi is highly selective and has no inhibitory effect on other SAM-dependent methyltransferases or NAD + salvage pathway enzymes

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