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Moreover, evidence have shown that mitophagy plays an indispensable role in the maintenance of osteoblast and osteoclast homeostasis (71, 72)

Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter

5d), p21 upregulation (Fig

In addition to its proteolytic cascades, uPAR are also involved in signaling events leading to cell proliferation, migration, angiogenesis, remodeling of the cell adhesion, cytokine release, priming of neutrophil for oxidant production and chemotaxis, all of which play a key role in the development, implantation and metastasis of tumors [88, 248]
